sodium resonium vs calcium resonium

Sodium polystyrene sulfonate was approved for medical use in the United States in 1958.[1]. -Obtain calcium, magnesium, sodium levels periodically Patient advice:-Tell patients to contact healthcare provider if constipation, diarrhea, bloody stools, confusion, weakness, or delayed though processes occur.-Caution patients to avoid taking antacids or laxatives with this drug (e.g., sorbitol, magnesium hydroxide) Common side effects include loss of appetite, gastrointestinal upset, constipation, and low blood calcium. François Dardel and Thomas V. Arden "Ion Exchangers" in, CS1 maint: multiple names: authors list (, "Sodium Polystyrene Sulfonate Monograph for Professionals", "Tolevamer, an Anionic Polymer, Neutralizes Toxins Produced by the BI/027 Strains of Clostridium difficile", "Ion-exchange resins for the treatment of hyperkalemia: are they safe and effective? Sodium zirconium cyclosilicate is a treatment option for people with high blood serum potassium levels (hyperkalaemia). Resonium A does not enter the bloodstream from the intestine. The usual dose is 15g three or four times a day. The dosage recommendations detailed in this section are a guide only; the precise requirements should be decided on the basis of regular serum electrolyte determinations. 2013 Sep;23(5):333-9. doi: 10.1053/j.jrn.2013.02.011. Action Cation exchange resin in sodium phase. [1] Effects generally take hours to days. Resonium A is a type of medicine used to help remove excessive amounts of potassium from the blood. 12-24 Talavera Road . Clinical studies on prophylaxis and treatment of secondary hyperparathyroidism in uremic patients on chronic dialysis. Your doctor, however, may prescribe Resonium A for another purpose. In its acid form, the resin is used as a solid acid catalyst in organic synthesis.[16]. Sodium polystyrene sulphonate (Resonium A) in sorbitol given as an enema or orally to treat hyperkalaemia has been described to induce intestinal necrosis in uraemic patients. Excipients with known effect: Saccharin sodium. Methods: 2017 Dec;49(12):2217-2221. doi: 10.1007/s11255-017-1717-5. vitamins, herbal supplements, etc. Monitor electrolytes. Calcium Resonium Powder contains Polystyrene Sulfonate as an active ingredient. Lowering a high level of potassium in the blood (hyperkalaemia), in people who are not passing urine, or who are having haemodialysis or peritoneal dialysis for kidney failure. It is passed (with the potassium ions) with the faeces. Resonium A contains a medicine called sodium polystyrene sulphonate. In this way, various salts of the polymer can be prepared, leading to sodium, calcium, and other salts: These ion-containing polymers are called ionomers. In artificial colon fluid, CPS increased Ca and decreased Na. 2014;39(3):252-9 Pretreatment of formula or expressed breast milk with sodium polystyrene sulfonate (Kayexalate(®)) as a treatment for hyperkalemia in infants with acute or chronic renal insufficiency. Use caution in congestive heart failure, severe hypertension, marked edema (due to sodium content; 1 g contains 100 mg of sodium, 1/3 of which is delivered to body) Best when used in non-life-threatening hyperkalemia. KAYEXALATE (sodium polystyrene sulfonate). ), allergies, pre-existing diseases, and current health conditions (e.g. Wong SWS, Zhang G, Norman P, Welihinda H, Wijeratne DT. Calcium Resonium is a type of medicine used to help remove excessive amounts of potassium from the blood. The resin is insoluble in water. Common examples include lithium, thyroxine, and digitalis. 2019 Sep 18;11(9):1520. doi: 10.3390/polym11091520. Georgianos PI, Liampas I, Kyriakou A, Vaios V, Raptis V, Savvidis N, Sioulis A, Liakopoulos V, Balaskas EV, Zebekakis PE. The calcium content is 1.6 to 2.4 mmol/g. Effects generally take hours to days. Calcium Resonium Powdercontains Polystyrene Sulfonate as an active ingredient. doi: 10.1002/14651858.CD013165.pub2. [8], A total of 58 cases of intestinal injury including necrosis of the colon have been reported with polystyrene sulfonate as of 2013. Calcium; Chronic kidney disease; Hyperkalemia; Potassium; Secondary hyperparathyroidism; Sodium. Unable to load your collection due to an error, Unable to load your delegates due to an error. Resonium A also contains vanillin. 2020 Jun 26;6(6):CD013165. Recently, the atom transfer radical polymerization (ATRP) of protected styrene sulfonates has been reported,[12][13] leading to well defined linear polymers, as well as more complicated molecular architectures. Calcium Resonium contains calcium polystyrene sulfonate which contains calcium atoms. Calcium Resonium Powder may also be used for purposes not listed in this medication guide. Calcium content is about 8% w/w (1.6-2.4 mmol/g). We also found that ΔNa and Δ(Na to chloride ratio) were positively correlated with ΔHCO3-. -, Postgrad Med J. 8600 Rockville Pike Clin J Am Soc Nephrol. [14], Polystyrene sulfonates are useful because of their ion exchange properties. Further information 1. Side effects: Bradycardia, hypotension and peripheral vasodilation. These polymers are classified as polysalts and ionomers.[15]. Site of action predominantly in the large intestine. Sci Rep. 2021 Jan 21;11(1):1890. doi: 10.1038/s41598-021-81501-3. 2020 Oct 30;7:2054358120965838. doi: 10.1177/2054358120965838. Resonium A contains sodium polystyrene sulfonate which contains sodium atoms. Resonium A does not enter the bloodstream from the intestine. Hyperkalaemia associated with anuria or severe oliguria, and in dialysis patients; Dose. Electrochemical Polymerization of PEDOT-Graphene Oxide-Heparin Composite Coating for Anti-fouling and Anti-clotting of Cardiovascular Stents. The hard ions such as calcium (Ca2+) and magnesium (Mg2+) adhere to the sulfonate groups, displacing sodium ions. 2015 Jul 29;4(8):e001959 Saccharin sodium. Potassium Binders for Hyperkalemia in Chronic Kidney Disease-Diet, Renin-Angiotensin-Aldosterone System Inhibitor Therapy, and Hemodialysis. Epub 2019 Oct 23. Resonium A Indication Treatment of hyperkalaemia [Plasma K+ 6-7mmol/L] in the absence of ECG changes. Adults, including the elderly: Oral. Although polystyrene sulfonate (PS) is commonly used for the treatment of hyperkalemia, direct comparison of effects between calcium and sodium PS (CPS and SPS) on mineral and bone metabolism has not yet been studied. Natale P, Palmer SC, Ruospo M, Saglimbene VM, Strippoli GF. On the other hand, the use of milder conditions such as acetyl sulfate leads to incomplete sulfonation. -, BMJ. [5], Intestinal disturbances are common, including loss of appetite, nausea, vomiting, and constipation. [6] Changes in electrolyte blood levels such as hypomagnesemia, hypocalcemia, and hypokalemia may occur. [9], Polystyrene sulfonates can bind to various drugs within the digestive tract and thus lower their absorption and effectiveness. Resonium A is a type of medicine used to help remove excessive amounts of potassium from the blood. Administer Calcium Resonium at least 3 hours before or 3 hours after other oral medications. Calcium Resonium Powder works by removing excess potassium in the blood. Cochrane Database Syst Rev. pregnancy, upcoming surgery, etc. National Library of Medicine This sodium is swapped for potassium in the body, particularly in the large intestine. Resonium A contains sodium polystyrene sulfonate which contains sodium atoms. Possible side eff ects 5. For the full list of excipients, see Section 6.1 List of Excipients. Sodium is the major cation of the extracellular fluid, constituting 90 to 95 per cent of all cations in the blood plasma and interstitial fluid; it thus determines the osmolality of the extracellular fluid. Page 2of 2. Resonium A is used to treat something called ‘hyperkalaemia’. When the resin reaches the large intestine the hydrogen ions are exchanged for free potassium ions; the resin is then eliminated in the feces. Excipients with known effect. This is when there is too much potassium in your blood. Find its price or cost and dose. In September 2017, the FDA recommended separating the dosing of polystyrene sulfonate from any other oral medications by at least three hours to avoid any potential interactions. Before you are given Calcium Resonium 3. Polystyrene sulfonates are a group of medications used to treat high blood potassium. It explained that sodium zirconium cyclosilicate would complement rather than replace the use of insulin and glucose in patients with life-threatening hyperkalaemia. Calcium Resonium je sulfónová katióny meniaca živica s vysokým obsahom naviazaných vápnikových iónov, ktorá má schopnosÅ¥ viazaÅ¥ draselné ióny na miesta vápnikových, čím odstraňuje z organizmu draslík. What Calcium Resonium is and what it is used for 2. Please enable it to take advantage of the complete set of features! Careers. In rare cases, it has been associated with colonic necrosis. Calcium Resonium Powder is used for High level of potassium in the blood and other conditions. It is manufactured by Pharma Synth Formulations Ltd. 2010 Jul 29;341:c3691 Mayo Clin Proc. Calcium polystyrene sulfonate is … Privacy, Help Crosslinking reactions are also found, where condensation of two sulfonic acid groups yields a sulfonyl crosslink. Results: This sodium is swapped for potassium in the body, particularly in the large intestine. [1] They are also used to remove potassium, calcium, and sodium from solutions in technical applications. It is also used to treat hyperkalaemia in patients requiring dialysis and in patients on regular haemodialysis or on prolonged peritoneal dialysis. Furthermore, SPS greatly reduced K, Mg, and NH3. Calcium content is about 8% w/w (1.6-2.4 mmol/g). They are also used to remove potassium, calcium, and sodium from solutions in technical applications. Resonium A does not enter the bloodstream from the intestine. This is the usual dosage recommended in most common treatment cases. This sodium is swapped for potassium in the body, particularly in the large intestine. Although polystyrene sulfonate (PS) is commonly used for the treatment of hyperkalemia, direct comparison of effects between calcium and sodium PS (CPS and SPS) on mineral and bone metabolism has not yet been studied. Can J Kidney Health Dis. Calcium Resonium contains 99.93% calcium polystyrene sulfonate ground and flavoured to a vanilla odour and sweet taste. In a randomized and crossover design, 20 pre-dialysis patients with hyperkalemia (>5 mmol/l) received either oral CPS or SPS therapy for 4 weeks. Would you like email updates of new search results? Double substitutions of the phenyl rings are known to occur, even with conversions well below 100%. Compared with SPS, CPS may be safer for the treatment of hyperkalemia in pre-dialysis patients, because it did not induce hyperparathyroidism or volume overload. How to store Calcium Resonium 6. Hyperkalemia is prevalent in end-stage renal disease patients, being involved in life-threatening arrhythmias. Calcium Resonium is an ion-exchange resin that is recommended for the treatment of hyperkalaemia associated with anuria or severe oliguria. Resonium A powder contains sodium polystyrene sulfonate, which is a type of medicine known as an ion-exchange resin. However, SPS significantly decreased serum calcium (Ca) and magnesium (Mg) and increased intact parathyroid hormone (iPTH) values, whereas CPS reduced iPTH. In a randomized and crossover design, 20 pre … -, Am J Nephrol. Calcium polystyrene sulfonate (Calcium Resonium®) – Adult. Background: Hyperkalemia is prevalent in end-stage renal disease patients, being involved in life-threatening arrhythmias. Calcium Resonium Dosage & How to Take. 2019 Jun;17(1):1-6. doi: 10.5049/EBP.2019.17.1.1. [15] Linear ionic polymers are generally water-soluble, whereas cross-linked materials (called resins) do not dissolve in water. Bethesda, MD 20894, Copyright This belongs to a group of medicines called ‘ion exchange resins’. In vito exchange capacity of approximately 3.1mEq [in … The sodium content is approximately 4.1mmol (100 mg) per gram of Resonium A. Excipients with known effect: saccharin sodium. Conclusion: 3 PHARMACEUTICAL FORM The resulting solution of sodium ions is softened. Manufacturer/Sponsor Calcium Resonium is made in France. After 4-week treatments, there was no significant difference of changes in serum potassium (K) from the baseline (ΔK) between the two groups. Avoid co-administration of Calcium Resonium with other orally administered medications. Epub 2015 Nov 17. 2015 Dec 7;10(12):2136-42. doi: 10.2215/CJN.03640415. -, J Am Heart Assoc. The associations between serum trace elements and bone mineral density in children under 3 years of age. The sodium (Na+) content of the resin is less than 1 mg/g. Evaluation of the tolerability and efficacy of sodium polystyrene sulfonate for long-term management of hyperkalemia in patients with chronic kidney disease. Pharmacology Calcium Gluconate is a myocardium stabiliser and is cardioprotective. Calcium Resonium Powderworks by removing excess potassium in the blood. Calcium Resonium Powder is used for High level of potassium in the blood and other conditions.Calcium Resonium Powdermay also be used for purposes not listed in this medication guide. Since the sulfonic acid group (SO3H) is strongly acidic, this polymer neutralizes bases. [10], Polystyrene sulfonates release sodium or calcium ions in the stomach in exchange for hydrogen ions. J Ren Nutr. Potassium binders for chronic hyperkalaemia in people with chronic kidney disease. FOIA [9] Well more cases have been reported when used in combination with sorbitol and other cases have occurred when used alone. [4], Polystyrene sulfonates are given by mouth with a meal or rectally by retention enema. eCollection 2020. 2. Although polystyrene sulfonate (PS) is commonly used for the treatment of hyperkalemia, direct comparison of effects between calcium and sodium PS (CPS and SPS) on mineral and bone metabolism has not yet been studied. -. Sodium polystyrene sulfonate is used as a superplastifier in cement, as a dye improving agent for cotton, and as proton exchange membranes in fuel cell applications. Large doses may result in fecal impaction, especially in the elderly Epub 2013 May 23. Calcium Resonium® (Calcium polystyrene sulphonate) Powder (£68.47 = 300g) Indications. ).Some health conditions may make you more susceptible to the side-effects of the drug. In emergency care, as an alternative to calcium resonium and permanently stopping RAAS inhibitors, in people with high levels of serum potassium who need immediate hospital treatment. Int Urol Nephrol. ÚčinnosÅ¥ výmeny draslíka je variabilná. 16k09637/Ministry of Education, Culture, Sports, Science and Technology of Japan, Kidney Int. COVID-19 is an emerging, rapidly evolving situation. Epub 2019 Jun 30. 1alpha(OH)D3 One-alpha-hydroxy-cholecalciferol--an active vitamin D analog. Resonium A contains sodium polystyrene sulfonate which contains sodium atoms. Resonium A contains sodium polystyrene sulfonate which contains sodium atoms. Pharmacologic Treatment of Chronic Hyperkalemia in Patients with Chronic Kidney Disease. A polystyrene sulfonate was developed in the 2000s to treat Clostridium difficile associated diarrhea under the name Tolevamer,[2] but it was never marketed. 3 PHARMACEUTICAL FORM Buff coloured very fine powder. Effect of resonium is slow with lowering of serum potassium taking hours to days Indication Hyperkalaemia (>10mmol/L) Water softening is achieved by percolating hard water through a bed of the sodium form of cross-linked polystyrene sulfonate. The effect is a reduction of potassium levels in the body, at a capacity of 1 mEq of potassium exchanged per 1 g of resin.[8][11]. The net effect is lowering the amount of potassium available for absorption into the blood and increasing the amount that is excreted via the feces. sodium [so´de-um] a chemical element, atomic number 11, atomic weight 22.990, symbol Na. Ca-Resonium is usually given 1 to 4 times daily by a … Polystyrene sulfonic acid, the acid whose salts are the polystyrene sulfonates, has the idealized formula (CH2CHC6H4SO3H)n. The material is prepared by sulfonation of polystyrene: Several methods exist for this conversion, which can lead to varying degree of sulfonation. 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Resonium A contains 99.93% sodium polystyrene sulfonate as a finely ground powder. Resonium A (sodium polystyrene sulfonate). Sodium polystyrene sulfonate can be given as a liquid by mouth, through a stomach feeding tube, or as a rectal enema. Polystyrene sulfonates are a group of medications used to treat high blood potassium. Resonium A is for oral or rectal administration only. It is used in the treatment of hyperkalaemia (too much potassium in the blood). Lepage L, Dufour AC, Doiron J, Handfield K, Desforges K, Bell R, Vallée M, Savoie M, Perreault S, Laurin LP, Pichette V, Lafrance JP. Macquarie Park NSW 2113 . Calcium Resonium is a calcium polysterene sulfonate (calcium exchange resin) Classification Resonium is a cation exchange resin, which results in exchanges calcium or sodium ions for potassium ions. Epub 2017 Oct 11. Prevention and treatment information (HHS). Electrolyte Blood Press. [3] However, it is unclear if it is beneficial and there is concern about possible side effects when it is combined with sorbitol. Before using Calcium Resonium Powder, inform your doctor about your current list of medications, over the counter products (e.g. 1995 Sep;71(839):551-2 2020 Feb;95(2):339-354. doi: 10.1016/j.mayocp.2019.05.019. Keywords: For the full list of excipients, see Section 6.1 List of excipients. Pharmacology Calcium Resonium is a large insoluble molecule that binds to K+ in the large intestine, where it is excreted in faeces. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history. Oral, 15g 3–4 times daily in a small amount of water or syrup (not fruit juice which has a high potassium content) Notes 1. ΔiPTH was inversely correlated with ΔCa and ΔMg (r = -0.53 and r = -0.50, respectively). It is passed (with the potassium ions) with the faeces. Background: This site needs JavaScript to work properly. Accessibility How Calcium Resonium is given 4. Calcium Resonium (15 mg) 15gm - 1 Sachet (Calcium Polystyrene Sulphonate Powder) drug information. Clipboard, Search History, and several other advanced features are temporarily unavailable. Calcium Resonium does not contain gluten, sucrose, lactose, tartrazine or any other azo dyes. [1] These polymers are derived from polystyrene by the addition of sulfonate functional groups. For patients with gastroparesis, a 6-hour separation should be considered (see Section 4.2 and Section 4.5). Usually the polystyrene is crosslinked, which keeps the polymer from dissolving. Calcium Resonium is supplied in Australia by: sanofi-aventis australia pty ltd . Randomized Clinical Trial of Sodium Polystyrene Sulfonate for the Treatment of Mild Hyperkalemia in CKD. ", FULL PRESCRIBING INFORMATION Revised 07/2017, "Safety Alerts for Human Medical Products - Kayexalate (sodium polystyrene sulfonate): Drug Safety Communication - FDA Recommends Separating Dosing", "Potassium-Binding Agents for the Clinical Management of Hyperkalemia", "Polymerization of Styrene Sulfonate Ethyl Ester and Styrene Sulfonate Dodecyl Ester by ATRP: Synthesis and Characterization of Polymer Brushes", "Stereoselective Synthesis of anti α-Methyl-β-Methoxy Carboxylic Compounds", https://en.wikipedia.org/w/index.php?title=Polystyrene_sulfonate&oldid=1002717053, Chemicals that do not have a ChemSpider ID assigned, Drugboxes which contain changes to verified fields, Drugboxes which contain changes to watched fields, Creative Commons Attribution-ShareAlike License, This page was last edited on 25 January 2021, at 19:19. [7] Polystyrene sulfonates should not be used in people with obstructive bowel disease and in newborns with reduced gut motility.